Connection Found Between Genetic Variants and Type 1 Diabetes Heterogeneity

A recent study published in Diabetes Care identified an association between certain variants of the transcription factor 7 like 2 (TCF7L2) gene at diagnosis of type 1 diabetes. Specifically, the major factor for expressing single autoantibiody at diagnosis was the rs4506565 variant.

Researchers used a group of 810 patients who were newly diagnosed with autoimmune type 1 diabetes. The mean age was 13.6, and it was found that the rs7901695 and rs4506565 variants of TCF7L2 were correlated to lower glucose and higher C-peptide. However, the association was only shown to be significant among participants at 12 years of age or older. No significant relationship was found for patients under the age of 12.

These findings were published in Diabetes Care on October 17, 2017.

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